Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution)

Aim : to review the modern approaches diagnosis and treatment of C. difficile -associated disease in adults present resolution Expert Council held on March 25, 2023 Moscow. General provisions . is most important nosocomial pathogen which spores are also commonly found environment. Microbiota impairment, primarily due use antibacterial drugs, a key stage development disease. A search for an infection should be carried out only patients with diarrhea, it advisable at least 2 laboratory methods. The drug choice first-line vancomycin. If ineffective or patient has recurrent clostridial infection, fecal microbiota transplantation considered. probiotic strain Saccharomyces boulardii CNCM I-745 direct inhibitory effect toxin A, promotes normalization intestinal composition, decreases inflammatory reaction colonic mucosa colonized toxigenic Conclusions Addition therapy both primary secondary prevention